Henley, Rosalind Venetia (1931) The cinchona alkaloids and substances related to them.
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A short survey is given of the known facts regarding the relation between the constitution and the antimalarial activity of the chief cinchona alkaloids, and it is concluded that further information on this matter can be obtained in two ways: (1). By investigating the degradation products and some of the simpler derivatives of these alkaloids. (2). By preparing some synthetic substances which contain certain characteristic features. Under heading (2), a large number of compounds of the general formula: [equation] have been synthesised. These all bear, as the formula indicates, marked pictorial resemblance to the essential cinchona structure. The antimalarial activity of the new substances has been determined, and the conclusion is drawn that a second basic centre must be present for a molecule of the above type to possess any marked antimalarial activity. Under heading (2), a number of alkaloid methochlorides have been prepared by a new process, and considerable attention has been paid to the attempted decarboxylation of quitenine, since the decarboxy-lated product should exhibit definite antimalarial activity. Experiments have also been performed on the preparation of quitenine amide, and of its benzoyl derivative.
This is a Accepted version This version's date is: 1931 This item is not peer reviewed
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Deposited by () on 31-Jan-2017 in Royal Holloway Research Online.Last modified on 31-Jan-2017
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